Incidence, Persistence, and Clearance of Anal Human Papillomavirus among Men Who Have Sex with Men in China: An Observational Cohort Study

Pathogens

Yi-Fan Lin¹  Yiguo Zhou¹  Huachun Zou¹  Tian Tian¹  Leiwen Fu¹  Ganfeng Luo¹  Xinyi Zhou¹  Peiyang Li²  Yong Lu²  Zhenyu Wang²  Jianghong Dai³  Zhenzhou Luo⁴  Xiaojun Meng⁵ 

[1] School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China;School of Public Health, Sun Yat-sen University, Guangzhou 510006, China;School of Public Health, Xinjiang Medical University, Urumqi 830011, China;Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518000, China;Wuxi Municipal Centre for Disease Control and Prevention, Wuxi 214023, China;

关键词: human papillomavirus;    men who have sex with men;    incidence;    persistence;    clearance;   

DOI  :  10.3390/pathogens11030314

来源: DOAJ

【 摘 要 】

(1) Background: We conducted a prospective observational cohort study to measure incidence, persistence, and clearance of anal human papillomavirus (HPV) among men who have sex with men (MSM) in China. (2) Methods: MSM were recruited in Guangzhou, Shenzhen and Wuxi, China in 2017. A tablet-based questionnaire was used to collect sociodemographic and behavioral characteristics. An anal brush sample was collected for HPV testing and genotyping. Participants were followed up 12 months after enrolment. (3) Results: A total of 196 participants completed two HPV tests with a median age of 27.3 (interquartile range (IQR) 24.0–32.8) years. Rate of incidence, persistence, and clearance for HPV among MSM were 31.3 (95% confidence interval (CI) 24.7–39.2), 47.9 (36.8–61.3), and 122.5 (104.3–143.0) per 1000 person months (pm), respectively. HPV 16 (4.1/1000 pm) had the highest incidence rate, and HPV 6 (47.4/1000 pm) had the highest persistence rate. Having lower education and engaging in receptive anal intercourse were potential risk factors of HPV incidence. A higher incidence rate was observed among younger MSM. (4) Conclusions: The high incidence and low clearance of anal HPV highlight the necessity of HPV vaccination among MSM. Further studies are needed to clarify the HPV dynamics at multiple anatomical sites and the burden of HPV-related diseases among MSM.

【 授权许可】

Unknown