Incidence, persistence, and clearance of anogenital human papillomavirus among men who have sex with men in Taiwan: a community cohort study

Frontiers in Immunology

Immunology

Yi-Fang Yu¹  Carol Strong¹  Tian Tian²  Yuwei Li²  Zhen Lu²  Xinyi Zhou²  Yi-Fan Lin²  Huachun Zou³  Yiguo Zhou⁴ 

[1] Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan;School of Public Health (Shenzhen), Sun Yat‐sen University, Shenzhen, China;School of Public Health (Shenzhen), Sun Yat‐sen University, Shenzhen, China;Kirby Institute, University of New South Wales, Sydney, Australia;School of Public Health, Peking University, Beijing, China;

关键词: human papillomavirus;    incidence;    persistence;    clearance;    men who have men with men;   

DOI  :  10.3389/fimmu.2023.1190007

 received in 2023-03-20, accepted in 2023-05-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundMen who have sex with men (MSM) have an increased risk of human papillomavirus (HPV) infection. This study aimed to assess the incidence, persistence, and clearance of anogenital HPV infections among MSM and the correlates in a 3-year community cohort study.MethodsFrom 2015 to 2019, MSM were recruited and followed up at 6, 12, 24, and 36 months in Taiwan. Questionnaires and anogenital swabs were collected at baseline and each follow-up visit. Thirty-seven HPV genotypes were tested and genotyped using the linear array HPV genotyping test. The incidence, persistence, and clearance rates of anogenital HPV infection and 95% confidence intervals (CIs) were estimated through Poisson regression. Correlates of the incidence and clearance rates were examined using a generalized estimating equations (GEE) model.ResultsA total of 201 MSM were retained in the cohort study with a median age of 27 years (interquartile range [IQR]: 24–32) at baseline. The incidence, persistence, and clearance rates of any anal HPV infection among MSM were 43.6 (95% CI: 33.7–55.6), 23.4 (17.7–30.2), and 58.3 (45.1–74.1) per 1,000 person months (pms), respectively. The incidence, persistence, and clearance rates of any penile HPV infection among MSM were 26.8 (20.1–34.9), 13.4 (8.0–20.9), and 51.5 (37.8–68.5) pms, respectively. MSM who did not consistently use a condom in receptive sex (adjusted odds ratio [AOR]: 2.06, 95% CIs: 1.14–3.72) were more likely to acquire any anal HPV infection. Age at recruitment (1.05, 1.01–1.09) was positively associated with any penile HPV incidence. MSM with over one sex partner in receptive anal sex (0.53, 0.30–0.94) were less likely to clear any anal HPV infection. MSM who were unemployed/students (0.55, 0.30–0.98) were less likely to clear any penile HPV infection.ConclusionHigh incidence and low clearance of anogenital HPV infection among MSM in the study serve as a reminder that this population needs to be targeted for HPV vaccination. It is essential for MSM to scale up HPV screening and adhere to safe sex.

【 授权许可】

Unknown   
Copyright © 2023 Zhou, Tian, Lu, Yu, Li, Zhou, Lin, Strong and Zou