Three new amide derivatives from the fungus Alternaria brassicicola

Natural Products and Bioprospecting

Short Communication

Jieru Guo¹  Saisai Gu²  Yonghui Zhang³  Shuyuan Mo³  Sitian Zhang³  Zhengxi Hu³  Fengli Li³ 

[1] Department of Pharmacy, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, 430033, Wuhan, China;Department of Pharmacy, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, 430022, Wuhan, China;Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China;

关键词: Alternaria brassicicola;    Secondary metabolites;    Amide derivatives;    Structural elucidation;   

DOI  :  10.1007/s13659-023-00391-2

 received in 2023-07-24, accepted in 2023-08-18,  发布年份 2023

来源: Springer

【 摘 要 】

Three new amide derivatives (alteralkaloids A–C, 1–3) and three known alkaloids (4–6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1–3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity.Graphical Abstract

【 授权许可】

CC BY   
© Kunming Institute of Botany, CAS 2023

【 图 表 】

Fig. 5

Fig. 2

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