Synthesis, structural elucidation and antimicrobial activities of 5-(3-nitrophenyllazo)-6-aminouracil and its complexes with some transition metal ions

4th International Conference on Advanced Sciences

工业技术;自然科学

Zaki, Z.M.^1 ; Abbas, S.M.^1 ; Dessoukii, H.A.^2 ; Awes, H.S.^1 ; Mahmoud, Rehab^3

Inorganic Chemistry Lab. Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt^1

Chemistry Department, Faculty of Science, Benha University, Egypt^2

Materials Science Lab, Chemistry Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt^3

关键词: Anti-microbial activity;    Complexometric titration;    Fragmentation patterns;    Magnetic susceptibility measurements;    Mass spectra;    Square planar geometry;    Structural elucidation;    Uracils;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/464/1/012009/pdf
DOI  :  10.1088/1757-899X/464/1/012009

来源: IOP

【 摘 要 】

In this study, 5-(3-nitrophenyllazo)-6-aminouracil was prepared by linking 3-nitro aniline to 6-aminouracil. The (1:1) complexes of this ligand with Fe+ 3, Co+2, Ni+2, Cu+2 and Zn+2 were prepared and characterized by elemental analysis for C, H and N, thermal analyses (TGA and DTA), FT-IR, 1H NMR. The molecular weight of the ligand was determined by mass spectral measurement and its fragmentation pattern was reported. The metal content of the complexes was determined by EDTA complexometric titrations and the coordination number of metal in complexes was confirmed by magnetic susceptibility measurements. Antimicrobial activities for ligand and its complexes were studied. The IR and 1H NMR studies confirmed that 5-(3-nitrophenyllazo)-6-minouracil behaves as monobasic bi dentate ligand bonding to the metal ion through both NH2 group and N=N groups forming six membered ring and The magnetic moments measurements indicated octahedral geometry for Fe+3 complex, tetrahedron structure for Co+2, Ni+2, Cu+2 complexes and square planar geometry for Zn+2 complex. Antimicrobial activity measurements indicated that Co+2 and Ni+2 complexes are biologically active towards bacteria gram (-ve), gram (+ ve) and fungi, while Zn+2 complex showed high resistance towards gram (+ ve) bacteria and medium resistance towards gram (-ve).