Co-circulation and co-infection of hantaviruses and Wenzhou mammarenavirus in small mammals and humans in Jiangxi, China

Frontiers in Microbiology

Microbiology

Zhiyong Xia¹  Yun Xie²  Xiaoqing Liu²  Shanshan Du³  Meijun Guo³  Jiandong Li³  Aqian Li³  Dexin Li³  Qin Wang³  Shiwen Wang³  Xiaoxia Huang³  Wei Wu³  Chuan Li³  Mifang Liang³  Lina Sun³  Xuefei Deng³  Zhao Chen⁴ 

[1] Gao’an City CDC, Gao’an, Jiangxi, China;Jiangxi Province CDC, Nanchang, Jiangxi, China;NHC Key Laboratory of Biosafety, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China;Yichun City CDC, Yichun, Jiangxi, China;

关键词: hantavirus;    Wenzhou mammarenavirus;    rodents;    co-infection;    HFRS;    Seoul virus (SEOV);    Hantaan virus (HTNV);   

DOI  :  10.3389/fmicb.2023.1225255

 received in 2023-05-19, accepted in 2023-06-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

Both Orthohantaviruses (HV) and Whenzhou Mammarenaviruses (WENV) are rodents borne viruses, allowing them to spread simultaneously in the same area and infect humans. To explore the potential threat of HV and WENV to public health safety, an environmental and laboratory investigation was conducted in 2020–2021, in Jiangxi province, China. A total of 461 small mammals of 7 species and paired sera from 43 suspected HFRS cases were collected from Jiangxi Province, China. Viral genomic RNA and specific antibodies against HV and WENV were detected to evaluate the epidemic situation of the two viruses. Hantaan virus (HTNV), seoul virus (SEOV) and WENV RNA were detected in the lungs of the captured mammals, which resulted 4.1% and 7.4% of HV and WENV RNA positive respectively. Co-infections of WENV and SEOV were detected from Rattus norvegicus, Mus musculus and Rattus flavipectus with an overall co-infection rate of 0.65%. The detection rates of antibodies in the blood against HV and WENV were 11.9% (55/461), and 13.2% (61/461) respectively. The prevalence of viral infection and viral genetic characters varied among the selected areas. In the paired sera of 43 suspected HFRS cases, 38 were with HV infection, 11 were with WENV IgG, and 7 with a 4-fold or more of WENV IgG titer elevation. These results revealed the fact of the co-circulating and coinfection of HV and WENV in the same area at the same time, which might impact on public health safety.

【 授权许可】

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Copyright © 2023 Du, Xie, Deng, Xia, Wu, Huang, Chen, Li, Li, Wang, Sun, Guo, Wang, Liang, Li, Liu and Li.