Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

Journal of Veterinary Medical Science

Jiro ARIKAWA¹  Yoichi TANIKAWA³  Daisuke MIYASHITA³  Ichiro NAKAMURA²  Vyacheslav G. MOROZOV⁴  Mariko ISHIZUKA³  Alexander E. BALAKIEV⁵  Kumiko YOSHIMATSU¹  Evgeniy A. TKACHENKO⁵  Nur Hardy bin Abu DAUD³  Tamara K. DZAGURNOVA⁵  Kentaro YOSHII³  Olga A. MEDVEDKINA⁵  Takahiro SETO³  Sergey N. BELOV⁴  Sergey I. KOLOMINOV⁴  Hiroaki KARIWA³  Ikuo TAKASHIMA³  Mina NAKAUCHI³  Nobuo HASHIMOTO³ 

[1] Graduate School of Medicine, Hokkaido University;Research Center for Zoonosis Control, Hokkaido University;Graduate School of Veterinary Medicine, Hokkaido University;Medical Company "Hepatolog" Incorporated;Chumakov Institute of Polyomyelitis and Viral Encephalitidis

关键词: epidemiology;    hantavirus;    hemorrhagic fever with renal syndrome;    Puumala virus;    rodents;   

DOI  :  10.1292/jvms.001569

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(47)Cited-By(6)European Russia is a highly endemic area of hemorrhagic fever with renal syndrome (HFRS), a rodent-borne zoonotic disease, caused by hantaviruses. In total, 145 small mammals of four species (Myodes glareolus, Apodemus flavicollis, A. agrarius, and A. uralensis) were trapped in the Samara region of European Russia in August 2005 and examined for the presence of hantavirus (HV). Anti-HV antibodies were found in six of 68 (8.8%) M. glareolus and in one of 19 (5.3%) A. flavicollis by indirect immunofluorescent antibody assay (IFA). The Puumala virus (PUUV), which is one of the hantavirus species, was detected in the lungs of seven M. glareolus by RT-PCR. The virus S-segment was extremely similar (96.2% to 99.3%) to the sequence found in a fatal case of HFRS in the Samara region. Phylogenetic analyses of S and M segments showed that the Samara PUUVs form a cluster within the Russian Volga lineage and apparently differ from other European PUUVs. Anti-PUUV antibodies were found in blood sera from seven HFRS patients and from one undiagnosed patient from the Samara region, using IFA and an enzyme-linked immunosorbent assay (ELISA). These data suggest that the bank vole M. glareolus is a primary natural reservoir and vector for PUUV, which is the main causative agent of HFRS in humans in the Samara region.

【 授权许可】

Unknown