Factors related to clinical severity of acute gastroenteritis in hospitalized children

Acute gastroenteritis;clinical severity;age;rotavirus;norovirus;co-infection;Clostridium difficile;Children;610

의과대학 의학과 ;

University:서울대학교 대학원

关键词: Acute gastroenteritis;    clinical severity;    age;    rotavirus;    norovirus;    co-infection;    Clostridium difficile;    Children;    610;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/142329/1/000000149301.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Background We aimed to investigate host- and pathogen-related factors associated with clinical severity of acute gastroenteritis (AGE) in hospitalized children. Methods From January 2012 to December 2013, fecal samples and clinical information including modified Vesikari scores were collected from children who were hospitalized with AGE. The presence of enteric viruses and bacteria including toxigenic Clostridium difficile was detected by polymerase chain reaction. Results Among the 415 children included, virus was detected in stool of 282 (68.0%) children. Co-infection with more than two viruses and toxigenic C. difficile were found in 24 (8.5%) and 26 (9.2%) children with viral AGE, respectively. Norovirus (n = 130) infection, including norovirus-associated co-infection, was the most frequent infection, especially in children aged < 24 months (P < 0.001). In the severity-related analysis, age < 24 months was associated with greater diarrheal severity (P < 0.001) and modified Vesikari score (P = 0.001), after adjustment for other severity-related factors including rotavirus status. Although the age at infection with rotavirus was higher than that for other viruses (P = 0.001), rotavirus detection was the most significant risk factor for all severity parameters, including modified Vesikari score (P < 0.001). Viral co-infection and toxigenic C. difficile co-detection were not associated with any severity-related parameter.Conclusion This study provides information on clinical severity related factors of childhood gastroenteritis, and this information will be helpful in the management of childhood AGE.