Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition

Frontiers in Medicine

Medicine

Shi Tang¹  Mengzhen Zhou² 

[1] Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China;Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China;

关键词: Alzheimer's disease;    cognition;    insomnia;    orexin;    treatment;   

DOI  :  10.3389/fmed.2022.984227

 received in 2022-07-01, accepted in 2022-11-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA.

【 授权许可】

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