Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

Sleep

Ueno, Takashi^2¹  Beuckmann, Carsten Theodor^1²  Nakagawa, Makoto^1³ 

[1] Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd., Tsukuba, Japan^2;Neurology Business Group, Discovery, Eisai Co., Ltd., Tsukuba, Japan^1;Pharmaceutical Regulatory Affairs Department, Marketing Authorization Group, EA Pharma Co., Ltd., Tokyo, Japan^3

关键词: antagonist;    dual orexin receptor antagonist;    E2006;    in vivo;    insomnia;    lemborexant;    mouse;    orexin;    rat;    sleep;   

DOI  :  10.1093/sleep/zsz076

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesTo present results from in vivo studies underlying the preclinical development of lemborexant (E2006), a novel dual orexin (hypocretin) receptor antagonist for sleep/wake regulation.

【 授权许可】

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