The effect of intermittent fasting on the clinical and hematological parameters of patients with sickle cell disease: A preliminary study

Frontiers in Medicine

Medicine

Mohamed Izham Mohamed Ibrahim¹  Yasamin Abdu²  Khalid Ahmed³  Mohamed A. Yassin³  Salma Mustafa⁴  Mohammad Affas⁴  Ehab Adam⁴  Ahmed Shukri⁴  Sief Khasawneh⁴  Abdullah Al Zayed⁵ 

[1] College of Pharmacy, QU Health, Qatar University, Doha, Qatar;Department of Community Medicine, Hamad Medical Corporation (HMC), Doha, Qatar;Department of Hematology, National Center for Cancer Care and Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar;Department of Internal Medicine, Hamad Medical Corporation (HMC), Doha, Qatar;Qatif Central Hospital, Qatif, Saudi Arabia;

关键词: sickle cell disease;    intermittent fasting;    vaso-occlusive crisis;    hemolytic crisis;    cbc;   

DOI  :  10.3389/fmed.2023.1097466

 received in 2022-11-13, accepted in 2023-02-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionSickle cell disease is a genetic disorder that frequently presents with vaso-occlusive crisis (VOC). Most patients with sickle cell disease in Qatar are Muslims; hence, they practice intermittent fasting during the holy month of Ramadan. However, there is a paucity of literature describing the effect of intermittent fasting on the occurrence of severe VOC. As a result, there is a lack of guidelines or standardized protocols that can help physicians advise patients with sickle cell disease who wish to practice intermittent fasting. Therefore, this study's aim was to investigate the effect of intermittent fasting on the clinical and hematological parameters of individuals with sickle cell disease.MethodsWe conducted a retrospective study for 52 Muslim patients with sickle cell disease in Qatar aged ≥18 years who were confirmed to be fasting during the holy month of Ramadan during any of the years 2019–2021. The difference in the occurrence of severe VOC, hemolytic crisis, and other clinical, hematological, and metabolic parameters were studied one month before, during, and one month after the intermittent fasting of Ramadan using the patient's medical records. Mean (sd), median (IQR), and frequency (%) described the data. One-way with repeated measures ANOVA with a Greenhouse-Geisser correction and Friedman tests (*) were used at alpha level 0.05.ResultsThe study participants' (mean±sd) age was (31.1±9.2) years, 51.9% were males, and 48.1% were females. Roughly seventy percent of the participants were of Arab ethnicity, while the rest were either African or Asian. Most of the patients were homozygotes (SS) (90.4%). The median number of severe VOC (P = 0.7) and hemolytic crisis (P = 0.5) was not found to be significantly different before, during, or after Ramadan. Significant differences, however, were found in platelet count (P = 0.003), reticulocyte count (P < 0.001), and creatinine level (P = 0.038) with intermittent fasting.DiscussionIn this preliminary study, intermittent fasting does not seem to influence the rate of occurrence of severe vaso-occlusive crisis or hemolytic crisis in patients with sickle cell disease; however, it was found to be associated with differences in platelet count, reticulocytes count, and creatinine level. The statistical and clinical significance of these findings needs to be confirmed in studies with a larger sample size.

【 授权许可】

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Copyright © 2023 Ahmed, Abdu, Khasawneh, Shukri, Adam, Mustafa, Affas, Mohamed Ibrahim, Al Zayed and Yassin.