Sickle Cell Disease in Pregnancy and Anaesthetic Implications: A Narrative Review

Journal of Obstetric Anaesthesia and Critical Care

article

Yudhyavir Singh¹  Alka Chabra²  Vineeta Venkateswaran¹  AnjanTrikha¹ 

[1] Anaesthesiology, Critical Care and Pain Medicine, AIIMS;Department of Anesthesia and Critical Care, Geetanjali Medical College and Hospital

关键词: Blood transfusion;    labour analgesia;    multimodal analgesia;    pregnancy;    sickle cell disease;    vaso-occlusive crisis;   

DOI  :  10.4103/JOACC.JOACC_76_21

学科分类：社会科学、人文和艺术（综合）

来源: Medknow

【 摘 要 】

Sickle cell disorder (SCD) is a genetic disorder of haemoglobin with a wide spectrum of severity and manifestations. It is a significant global public health problem and is mainly widespread among many tribal populations. Sickle cell disease (SCD) in pregnancy poses a unique challenge due to the physiological changes in pregnancy, the multitude of various organs involved, and its complications. The databases of PubMed, MedLine ResearchGate, EMbase, Scopus and Google Scholar were searched for literature about SCDs published up to 2021. Search terms and phrases used were 'sickle cell disease', 'sickle cell disease and pregnancy', 'anaesthesia and analgesia in sickle cell disease' and 'transfusion in sickle cell disease'. Original articles, guidelines, review articles, case reports, letters to editor and abstracts were reviewed with particular focus on pathophysiology and anaesthetic implications of sickle cell anaemia with pregnancy. While ample literature is available on SCDs, there is a paucity of literature on SCDs with pregnancy. In this review, we have attempted to present the relevant literature in a comprehensible manner.

【 授权许可】

CC BY-NC-SA