Dysfunction of basal ganglia functional connectivity associated with subjective and cognitive fatigue in multiple sclerosis

Frontiers in Neuroscience

Neuroscience

Angela Davies Smith¹  Rosemary Jones¹  Christelle Langley²  Ngoc Jade Thai³  Jared Bruce⁴  Simon Godwin⁵  Naoki Masuda⁶  Giovanni De Marco⁷ 

[1] Bristol and Avon Multiple Sclerosis Centre, The Brain Centre, Southmead Hospital, Bristol, United Kingdom;CRIC Bristol, Bristol Medical School, University of Bristol, Bristol, United Kingdom;Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom;CRIC Bristol, Bristol Medical School, University of Bristol, Bristol, United Kingdom;Mental Health Research for Innovation Centre, Mersey Care NHS Foundation Trust, Hollins Park House, Warrington, United Kingdom;Department of Biomedical and Health Informatics, University of Missouri – Kansas City School of Medicine, Kansas City, MO, United States;Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom;Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom;Department of Mathematics, State University of New York at Buffalo, Buffalo, NY, United States;Laboratoire CeRSM (EA-2931), UPL, Université Paris Nanterre, Nanterre, France;

关键词: multiple sclerosis;    fatigue;    basal ganglia;    neuroimaging;    functional connectivity;   

DOI  :  10.3389/fnins.2023.1194859

 received in 2023-03-27, accepted in 2023-05-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesCentral fatigue is one of the most common symptoms in multiple sclerosis (MS). It has a profound impact on quality of life and a negative effect on cognition. Despite its widespread impact, fatigue is poorly understood and very difficult to measure. Whilst the basal ganglia has been implicated in fatigue the nature of its role and involvement with fatigue is still unclear. The aim of the present study was to establish the role of the basal ganglia in MS fatigue using functional connectivity measures.MethodsThe present study examined the functional connectivity (FC) of the basal ganglia in a functional MRI study with 40 female participants with MS (mean age = 49.98 (SD = 9.65) years) and 40 female age-matched (mean age = 49.95 (SD = 9.59) years) healthy controls (HC). To measure fatigue the study employed the subjective self-report Fatigue Severity Scale and a performance measure of cognitive fatigue using an alertness-motor paradigm. To distinguish physical and central fatigue force measurements were also recorded.ResultsThe results suggest that decreased local FC within the basal ganglia plays a key role in cognitive fatigue in MS. Increased global FC between the basal ganglia and the cortex may sub serve a compensatory mechanism to reduce the impact of fatigue in MS.ConclusionThe current study is the first to show that basal ganglia functional connectivity is associated with both subjective and objective fatigue in MS. In addition, the local FC of the basal ganglia during fatigue inducing tasks could provide a neurophysiological biomarker of fatigue.

【 授权许可】

Unknown   
Copyright © 2023 Langley, Masuda, Godwin, De Marco, Smith, Jones, Bruce and Thai.