Multiple sclerosis-related fatigue lacks a unified definition: A narrative review

Journal of Research in Medical Sciences

关键词: diagnosis;    epidemiology;    etiology;    fatigue;    multiple sclerosis;    neuroimaging;    physiopathology;    risk factors;    therapy;   

DOI  :  10.4103/jrms.jrms_1401_20

来源: DOAJ

【 摘 要 】

Fatigue is the most common symptom in multiple sclerosis (MS). Although MS-related fatigue (MS-F) strongly affects quality of life and social performance of patients, there is currently a lack of knowledge about its pathophysiology, which in turns leads to poor objective diagnosis and management. Recent studies have attempted to explain potential etiologies as well as treatments for MS-F. However, it seems that without a consensus on its nature, these data could not provide a route to a successful approach. In this Article, we review definitions, epidemiology, risk factors and correlated comorbidities, pathophysiology, assessment methods, neuroimaging findings, and pharmacological and nonpharmacological treatments of MS-F. Further studies are warranted to define fatigue in MS patients more accurately, which could result in precise diagnosis and management.

【 授权许可】

Unknown