Multiple Sclerosis Journal – Experimental, Translational and Clinical | |
Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation: | |
Brian M Sandroff1  Robert W Motl1  Glenn R Wylie2  John DeLuca2  Curtis L Johnson3  Brad P Sutton4  | |
[1] 9968University of Alabama at Birmingham, USA;Kessler Foundation, USA;University of Delaware, USA;University of Illinois at Urbana-Champaign, USA | |
关键词: Exercise; cognition; neuroimaging; multiple sclerosis; rehabilitation; functional connectivity; | |
DOI : 10.1177/2055217318760641 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus (dâ=â1.92) and left medial frontal gyrus (dâ=â1.70). There further were moderate-to-large intervention effects on CPS (dâ=â0.72). Such preliminary data highlight FC within thalamocortical circuitry as a potential target for rehabilitation interventions for improving CPS in cognitively impaired individuals with MS.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201902025340221ZK.pdf | 198KB | download |