Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation:

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Brian M Sandroff¹  Robert W Motl¹  Glenn R Wylie²  John DeLuca²  Curtis L Johnson³  Brad P Sutton⁴ 

[1] 9968University of Alabama at Birmingham, USA;Kessler Foundation, USA;University of Delaware, USA;University of Illinois at Urbana-Champaign, USA

关键词: Exercise;    cognition;    neuroimaging;    multiple sclerosis;    rehabilitation;    functional connectivity;   

DOI  :  10.1177/2055217318760641

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Exercise training has been identified as a highly promising approach for managing the cognitive consequences of multiple sclerosis (MS). This study represents a secondary analysis of resting-state functional connectivity (RSFC) magnetic resonance imaging data from a pilot treadmill walking exercise training intervention for improving cognitive processing speed (CPS) in MS. There were large intervention effects on RSFC between the thalamus and right superior frontal gyrus (d = 1.92) and left medial frontal gyrus (d = 1.70). There further were moderate-to-large intervention effects on CPS (d = 0.72). Such preliminary data highlight FC within thalamocortical circuitry as a potential target for rehabilitation interventions for improving CPS in cognitively impaired individuals with MS.

【 授权许可】

CC BY-NC