Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues

Frontiers in Immunology

Immunology

Jacques-Olivier Pers¹  Johan Noble²  Nathalie Sturm³  Diane Giovannini³  Mitsuhiro Kawano⁴  Giovanna Clavarino⁵  Chantal Dumestre-Perard⁵  Bertrand Huard⁶  Aude Belbezier⁷  Laurence Bouillet⁷  Athan Baillet⁸ 

[1] B Lymphocytes, Autoimmunity and Immunotherapies, Brest University, INSERM, UMR1227, Brest, France;Odontology Unit, Brest University Hospital, Brest, France;Department of Nephrology, Grenoble University Hospital, Grenoble, France;Department of Pathology, Grenoble University Hospital, Grenoble, France;Translational Research in Autoimmunity and Inflammation Group (TRAIG), Translational Innovation in Medicine and Complexity (TIMC), University Grenoble-Alpes, CNRS Unité mixte de recherche (UMR) 5525, Grenoble, France;Department of Rheumatology, Kanazawa University Hospital, Kanazawa, Japan;Immunology Laboratory, Grenoble University Hospital, Grenoble, France;Translational Research in Autoimmunity and Inflammation Group (TRAIG), Translational Innovation in Medicine and Complexity (TIMC), University Grenoble-Alpes, CNRS Unité mixte de recherche (UMR) 5525, Grenoble, France;Translational Research in Autoimmunity and Inflammation Group (TRAIG), Translational Innovation in Medicine and Complexity (TIMC), University Grenoble-Alpes, CNRS Unité mixte de recherche (UMR) 5525, Grenoble, France;Department of Internal Medicine, Grenoble University Hospital, Grenoble, France;Translational Research in Autoimmunity and Inflammation Group (TRAIG), Translational Innovation in Medicine and Complexity (TIMC), University Grenoble-Alpes, CNRS Unité mixte de recherche (UMR) 5525, Grenoble, France;Department of Rheumatology, Grenoble University Hospital, Grenoble, France;

关键词: plasma cells;    antibodies;    autoimmunity;    tissues;    treatment;   

DOI  :  10.3389/fimmu.2023.1111366

 received in 2022-11-29, accepted in 2023-01-27,  发布年份 2023

来源: Frontiers

【 摘 要 】

The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in total serum immunoglobulins, among which are found autoantibodies that may be pathogenic by themselves and/or propagate the inflammatory reaction. The infiltration of autoimmune tissues by antibody-secreting cells (ASCs) constitutes another dysfunction. The known high dependency of ASCs on the microenvironment to survive combined to the high diversity of infiltrated tissues implies that ASCs must adapt. Some tissues even within a single clinical autoimmune entity are devoid of infiltration. The latter means that either the tissue is not permissive or ASCs fail to adapt. The origin of infiltrated ASCs is also variable. Indeed, ASCs may be commonly generated in the secondary lymphoid organ draining the autoimmune tissue, and home at the inflammation site under the guidance of specific chemokines. Alternatively, ASCs may be generated locally, when ectopic germinal centers are formed in the autoimmune tissue. Alloimmune tissues with the example of kidney transplantation will also be discussed own to their high similarity with autoimmune tissues. It should also be noted that antibody production is not the only function of ASCs, since cells with regulatory functions have also been described. This article will review all the phenotypic variations indicative of tissue adaptation described so for at the level of ASC-infiltrating auto/alloimmune tissues. The aim is to potentially define tissue-specific molecular targets in ASCs to improve the specificity of future autoimmune treatments.

【 授权许可】

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Copyright © 2023 Giovannini, Belbezier, Baillet, Bouillet, Kawano, Dumestre-Perard, Clavarino, Noble, Pers, Sturm and Huard