Avian Diagnostic and Therapeutic Antibodies

Bradley, David Sherman¹ 

[1] UND SMHS

关键词: Therapeutic and diagnostic avian antibodies;   

DOI  :  10.2172/1114116
RP-ID  :  DOE UND SC0005752
PID  :  OSTI ID: 1114116

学科分类：生物科学（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.