The role of lipo-oligosaccharide ganglioside mimicry on the interaction of Guillain-Barré syndrome associated strains of Campylobacter jejuni with the immune system

QR180 Immunology;QR Microbiology;RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

Easton, Alistair Scott ; Willison, Hugh J.

University:University of Glasgow

Department:Institute of Neuroscience and Psychology

关键词: Guillain Barre syndrome, GBS, campylobacter jejuni, immune response, lipo-oligosaccharide, LOS, gangliosides, siglecs, auto-antibody, mimicry, autoimmunity;   

Others  :  http://theses.gla.ac.uk/2019/1/2010eastonphd.pdf

来源: University of Glasgow

【 摘 要 】

The post infectious paralytic autoimmune disease, Guillain-Barré syndrome (GBS), has been associated with the generation of cross-reactive auto-antibodies after Campylobacter jejuni infection. These auto-antibodies interact with both the ganglioside mimicking C. jejuni lipo-oligosaccharides (LOS) and endogenous gangliosides.This study sought to investigate novel interactions of the ganglioside mimicking LOS with immune system ganglioside specific receptors. In addition, studies investigated if such receptor recognition affects antigen trafficking or the immunostimulatory potency of the LOS, which could participate in auto-antibody generation. Results presented in this thesis demonstrate for the first time that certain members of the siglec receptor family are capable of recognising LOS from a GBS associated strain of C. jejuni. This interaction did not definitively result in enhanced, or altered, potency of ganglioside mimicking LOS in stimulating immune cells.Interestingly, ganglioside mimicry was shown to enhance phagocytosis of C. jejuni, however, in vivo differences in bacterial trafficking were not observed.