Triclosan is associated with breast cancer via oxidative stress and relative telomere length

Frontiers in Public Health

Public Health

Ke Shi¹  Caibo Ning¹  Yimin Cai¹  Zequn Lu¹  Yanmin Li¹  Rong Zhong¹  Xiaomin Cai¹  Ming Zhang¹  Can Chen¹  Xiaoping Miao¹  Lu Wang¹  Linyun Fan¹  Ying Zhu²  Jianbo Tian²  Heng He³  Haijie Li⁴  Tianyi Dong⁵  Heng Li⁶  Tianrun Ye⁶ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Epidemiology and Biostatistics, School of Public Health, Wuhan University; Research Center of Public Health, Renmin Hospital of Wuhan University, Wuhan, China;Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China;Department of Gastrointestinal Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: TCS;    BC;    8-OHdG;    HNE-MA;    8-isoPGF;    RTL;    mediation effect;   

DOI  :  10.3389/fpubh.2023.1163965

 received in 2023-02-11, accepted in 2023-04-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionTriclosan (TCS), a widely prescribed broad-spectrum antibacterial agent, is an endocrine-disrupting chemical. The relationship and biological mechanisms between TCS exposure and breast cancer (BC) are disputed. We aimed to examine the correlation between urinary TCS exposure and BC risk and estimated the mediating effects of oxidative stress and relative telomere length (RTL) in the above association.MethodsThis case-control study included 302 BC patients and 302 healthy individuals in Wuhan, China. We detected urinary TCS, three common oxidative stress biomarkers [8-hydroxy-2-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoPGF2α), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)], and RTL in peripheral blood mononuclear cells.ResultsSignificant associations were observed between log-transformed urinary concentrations of TCS, 8-OHdG, HNE-MA, 8-isoPGF2α, RTL, and BC risk, with the odds ratios (95% confidence intervals) being 1.58 (1.32–1.91), 3.08 (1.55–6.23), 3.39 (2.45–4.77), 3.99 (2.48–6.54), and 1.67 (1.35–2.09), respectively. Continuous TCS exposure was significantly positively correlated with RTL, HNE-MA, and 8-isoPGF2α (all p<0.05) but not with 8-OHdG (p = 0.060) after adjusting for covariates. The mediated proportions of 8-isoPGF22α and RTL in the relationship between TCS and BC risk were 12.84% and 8.95%, respectively (all p<0.001).DiscussionIn conclusion, our study provides epidemiological evidence to confirmed the deleterious effects of TCS on BC and indicated the mediating effect of oxidative stress and RTL on the correlation between TCS and BC risk. Moreover, exploring the contribution of TCS to BC can clarify the biological mechanisms of TCS exposure, provide new clues for the pathogenesis of BC, which is of great significance to improving public health systems.

【 授权许可】

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Copyright © 2023 Cai, Ning, Fan, Li, Wang, He, Dong, Cai, Zhang, Lu, Chen, Shi, Ye, Zhong, Tian, Li, Li, Zhu and Miao.