Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer’s disease

Frontiers in Aging Neuroscience

Neuroscience

Ye Zhang¹  Yingxu Liu¹  Taizen Nakase²  Naoki Tomita²  Yasuko Tatewaki²  Michiho Muranaka²  Yumi Takano²  Yasuyuki Taki³  Tatsuo Nagasaka⁴  Haixia Zheng⁵  Benjamin Thyreau⁶ 

[1] Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;Department of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, Japan;Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;Department of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, Japan;Smart-Aging Research Center, Tohoku University, Sendai, Japan;Division of Radiology, Tohoku University Hospital, Sendai, Japan;Laureate Institute for Brain Research, Tulsa, OK, United States;Smart-Aging Research Center, Tohoku University, Sendai, Japan;

关键词: gray matter volume;    systemic inflammation;    C-reactive protein;    FreeSurfer;    subjective cognitive decline;    Alzheimer’s disease;   

DOI  :  10.3389/fnagi.2023.1227325

 received in 2023-05-23, accepted in 2023-07-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionPresent study was to investigate hs-CRP concentration, brain structural alterations, and cognitive function in the context of AD [Subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD].MethodsWe retrospectively included 313 patients (Mean age = 76.40 years, 59 SCD, 101 MCI, 153 AD) in a cross-sectional analysis and 91 patients (Mean age = 75.83 years, 12 SCD, 43 MCI, 36 AD) in a longitudinal analysis. Multivariable linear regression was conducted to investigate the relationship between hs-CRP concentration and brain structural alterations, and cognitive function, respectively.ResultsHs-CRP was positively associated with gray matter volume in the left fusiform (β = 0.16, pFDR = 0.023) and the left parahippocampal gyrus (β = 0.16, pFDR = 0.029). Post hoc analysis revealed that these associations were mainly driven by patients with MCI and AD. The interaction of diagnosis and CRP was significantly associated with annual cognitive changes (β = 0.43, p = 0.008). Among these patients with AD, lower baseline CRP was correlated with greater future cognitive decline (r = −0.41, p = 0.013).ConclusionOur study suggests that increased hs-CRP level may exert protective effect on brain structure alterations and future cognitive changes among patients already with cognitive impairment.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Tatewaki, Nakase, Liu, Tomita, Thyreau, Zheng, Muranaka, Takano, Nagasaka and Taki.