Multiple Sclerosis Journal �C Experimental, Translational and Clinical | |
Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study | |
article | |
Viktor Grut1  Martin Biström1  Jonatan Salzer1  Pernilla Stridh2  Anna Lindam4  Lucia Alonso-Magdalena5  Oluf Andersen6  Daniel Jons6  Martin Gunnarsson7  Magnus Vrethem8  Johan Hultdin9  Peter Sundström1  | |
[1] Department of Clinical Science, Neurosciences, Umeå University;Department of Clinical Neuroscience, Karolinska Institutet;Center for Molecular Medicine, Karolinska University Hospital;Department of Public Health and Clinical Medicine, Unit of Research, Education and Development Östersund Hospital, Umeå University;Department of Neurology, Skåne University Hospital and Department of Clinical Sciences, Neurology, Lund University;Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg;Department of Neurology, Faculty of Medicine and Health, Örebro University;Department of Neurology and Department of Biomedical and Clinical Sciences ,(BKV), Linköping University;Department of Medical Biosciences, Clinical Chemistry, Umeå University | |
关键词: Case-control studies; C-reactive protein; systemic inflammation; multiple sclerosis; | |
DOI : 10.1177/20552173221139768 | |
来源: Sage Journals | |
【 摘 要 】
Background: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP inyoung persons have been suggested to decrease the risk of multiple sclerosis (MS).Objectives: To assess CRP as a risk factor for MS.Methods: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837individuals who later developed MS and 984 matched controls. The risk of developing MS was analysedby conditional logistic regression on z-scored CRP values.Results: Levels of CRP were not associated with MS risk.Conclusions: We found no association between CRP levels and risk of MS development.
【 授权许可】
Unknown
【 预 览 】
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