Assessment of bladder filling during prostate cancer radiation therapy with ultrasound and cone-beam CT

Frontiers in Oncology

Oncology

Robin Landy¹  Jackson May¹  Timothy Dean Malouff²  Daniel Miller³  Daniel Michael Trifiletti⁴  Steven Buskirk⁴  Steve Herchko⁴  Karen Ryan⁴  Gerald Strong⁴  Mark R. Waddle⁵  Kiran Chauhan⁵  Daniel K. Ebner⁵  Katherine Tzou⁶  Tasmeem Kaleem⁷  William Stross⁸  Robert Clell Miller⁹  Chris Serago^1,10 

[1] College of Medicine, Florida State University, Tallahassee, FL, United States;Department of Radiation Oncology, College of Medicine, University of Oklahoma, Oklahoma City, OK, United States;Department of Radiation Oncology, Gamma West Cancer Center, Idaho Falls, ID, United States;Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, United States;Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States;Department of Radiation Oncology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States;Department of Radiation Oncology, Trihealth System, Cincinnati, OH, United States;Department of Radiation Oncology, United States Department of Veterans Affairs, Minneapolis, MN, United States;Department of Radiation Oncology, University of Tennessee Medical Center, Knoxville, TN, United States;Department of Therapeutic Radiology, School of Medicine, Yale University, New Haven, CT, United States;

关键词: bladder filling;    IMRT;    radiotherapy;    CBCT;    workflow;   

DOI  :  10.3389/fonc.2023.1200270

 received in 2023-04-04, accepted in 2023-07-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Prostate cancer patients undergoing external beam radiation therapy (EBRT) benefit from a full bladder to decrease bowel and bladder toxicity. Ultrasound may offer a proxy metric for evaluation, sparing CBCT dosing. Patients were prospectively enrolled pre-simulation from January 2017 to February 2018. Bladder volume was evaluated prior to RT using US daily and CBCT for three daily treatments and then weekly unless otherwise indicated. 29 patients completed median 40 days of RT, resulting in 478 CBCT and 1,099 US bladder volumes. 21 patients were treated to intact glands and 8 to the post-prostatectomy bed. Median patient age was 70 years. Bladder volume on CBCT and US positively correlated (r = 0.85), with average bladder volume for all patients of 162 mL versus 149 mL, respectively. Bladder volume during treatment was consistently lower than the volume at CT simulation (153 mL vs 194 mL, p<0.01) and progressively declined during treatment. Patients older than 70 years presented with lower average bladder volumes than those < 70 years (122 mL vs 208 mL, respectively, p<0.01). Patients with the highest agreement between CBCT and US (<10% variability) had higher average bladder volumes (192 mL vs 120 mL, p=0.01). US was found to be an accurate measure of bladder volume and may be used to monitor daily bladder volumes in patients being treated with radiation for prostate cancer.

【 授权许可】

Unknown   
Copyright © 2023 Chauhan, Ebner, Tzou, Ryan, May, Kaleem, Miller, Stross, Malouff, Landy, Strong, Herchko, Serago, Trifiletti, Miller, Buskirk and Waddle