The accuracy of cone beam computed tomography (CBCT) to determine newly formed bone within grafted maxillary sinus in sheep

CBCT;µCT;Maxillary;sinus;graft;cone;beam;tomograpjy;micro-CT;radiomorphometric;analysis

Ko, David (Seung Young) ; Duncan, Warwick ; Leichter, Jonathan ; Schwass, Don ; Schmidlin, Patrick ; McNaughton, Andrew

University of Otago

关键词: CBCT;    µCT;    Maxillary;    sinus;    graft;    cone;    beam;    tomograpjy;    micro-CT;    radiomorphometric;    analysis;   

Others  :  https://ourarchive.otago.ac.nz/bitstream/10523/6055/4/KoDavid2015DClinDent.pdf

美国|英语

来源: Otago University Research Archive

【 摘 要 】

Grafting of the maxillary sinus floor has become a common surgical intervention to increase bone volume for implant placement (Wallace and Froum, 2003); the procedure can be performed either as an 1-stage procedure with simultaneous implant placement or as a 2-stage procedure before implant placement (Bruggenkate and Bergh, 1998). In a 2-stage procedure, the chosen graft material is placed into the sinus floor and the graft material is left to consolidate with newly formed bone. This consolidation should preferably occur before implant placement. However, currently there is no clinical tool to assess healing within the grafted sinus. A trephine bone biopsy can be harvested for histological assessment but this is invasive and not clinically useful. The current clinical guideline is to wait between six to twelve months after maxillary sinus grafting before implant placement (Rodriguez et al., 2003) CBCT (Cone beam computed tomography) is a clinical 3-D (three-dimensional) radiographic tool for assessment of mineralised tissue (Ehrhart et al., 2008; Estrela et al., 2008) and may be used for assessment of graft healing within maxillary sinus. However, there are a limited number of studies looking at the use of CBCT in bone-density measurements (Benavides et al., 2012). Micro-computed tomography (µCT) is a 3-D radiographic tool mainly used for in vitro studies. Specimens with a volume of approximately 5cm3 can be scanned with up to a 1µm voxel resolution producing high-resolution radiographic images for mineralised tissues. There is growing evidence to suggest that µCT can be used as a substitute method for histology to measure mineralised tissue, particularly trabecular bone (Thomsen et al., 2000; Thomsen et al., 2005). With no clinical tool available for assessment of graft healing within the sinus, the purpose of this study was to assess whether CBCT can be used to measure the amount of newly formed bone in grafted maxillary sinus in sheep. To validate this, CBCT was compared with two reference standards; micro-computed tomography (µCT) and histology. Aim: To assess the effectiveness of CBCT for quantifying newly formed bone within grafted sinus sites, using an animal model. Method:Maxillary sinus grafting in six sheep with bovine xenograft (Endobon®) was evaluated after a sixteen-week healing period. Specimens from each animal were analysed using three imaging techniques: CBCT, µCT and resin-embedded histological sections. Two-dimensional