Case Report: Resolution of Lichen Planus Pemphigoides as an unexpected outcome of SARS-CoV-2 infection

Frontiers in Immunology

Immunology

Marzia Caproni¹  Alice Verdelli¹  Lavinia Quintarelli¹  Vincenza Maio²  Daniela Massi³  Alberto Corrà⁴  Elena Biancamaria Mariotti⁴  Cristina Aimo⁴  Beatrice Bianchi⁴  Elena Del Bianco⁴  Valentina Ruffo di Calabria⁴ 

[1] Rare Skin Diseases Unit, Department of Health Sciences, Azienda USL Toscana Centro (ERN-SKIN), University of Florence, Florence, Italy;Section of Anatomic Pathology, Azienda USL Toscana Centro, Florence, Italy;Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy;Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy;

关键词: SARS-CoV-2;    COVID-19;    autoimmunity;    viral infections;    Lichen planus pemphigoides;    molecular mechanisms;   

DOI  :  10.3389/fimmu.2023.1222459

 received in 2023-05-14, accepted in 2023-06-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

It is well known that viral infections play a relevant role in inducing or protecting from autoimmune diseases, thus representing a major environmental factor in the disruption of the immune system in genetically susceptible individuals. Since the beginning of the Covid-19 pandemic a great number of clinical and epidemiological studies have demonstrated that SARS-CoV-2 infection is no exception to the rule by interfering on many different levels in the normal functioning of our immune system. Even though a growing number of case series and case reports has been cited in the literature linking the infection to the new onset of autoimmune diseases, to date very little has been reported concerning a possible correlation between the virus and the clinical resolution of any kind of autoimmune pathology. Here we describe an interesting case of abrupt and unexpected resolution of Lichen planus pemphigoides mucocutaneous lesions in a fully vaccinated patient after a mildly symptomatic SARS-CoV-2 respiratory infection and we speculate on the possible underlying mechanisms correlating the two events.

【 授权许可】

Unknown   
Copyright © 2023 Ruffo di Calabria, Verdelli, Quintarelli, Corrà, Mariotti, Aimo, Del Bianco, Bianchi, Maio, Massi and Caproni