Host Genetics at the Intersection of Autoimmunity and COVID-19: A Potential Key for Heterogeneous COVID-19 Severity

Frontiers in Immunology

Mevhibe B. Hocaoglu²  Bahar Taneri⁴  Adil Seytanoglu⁷  Ilgin Cagnan⁷  Deniz Balci⁷  Halin Bareke⁸  Tugce Karaderi⁹  Nilufer Rahmioglu^1,10  Imge Kunter^1,11  Burc Barin^1,12  Esra Asilmaz^1,13 

[1] Palliative Care, King’s College London, London, United Kingdom;;Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery &0Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom;1Department of Gastroenterology, Homerton University Hospital, Clapton, United Kingdom;Center for Health Data Science, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark;;Cicely Saunders Institute of Palliative Care, Policy &Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus;Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Institute of Health Sciences, Marmara University, Istanbul, Turkey;Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark;Dr Fazil Kucuk Faculty of Medicine, Eastern Mediterranean University, Famagusta, Cyprus;Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, Cyprus;Vaccines and Infectious Diseases Therapeutic Research Area, The Emmes Company, Rockville, MD, United States;Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom;

关键词: COVID-19;    SARS-CoV-2;    immune response;    autoimmunity;    host genetics;    susceptibility;   

DOI  :  10.3389/fimmu.2020.586111

来源: DOAJ

【 摘 要 】

COVID-19 presentation is very heterogeneous across cases, and host factors are at the forefront for the variables affecting the disease manifestation. The immune system has emerged as a key determinant in shaping the outcome of SARS-CoV-2 infection. It is mainly the deleterious unconstrained immune response, rather than the virus itself, which leads to severe cases of COVID-19 and the associated mortality. Genetic susceptibility to dysregulated immune response is highly likely to be among the host factors for adverse disease outcome. Given that such genetic susceptibility has also been observed in autoimmune diseases (ADs), a number of critical questions remain unanswered; whether individuals with ADs have a significantly different risk for COVID-19–related complications compared to the general population, and whether studies on the genetics of ADs can shed some light on the host factors in COVID-19. In this perspective, we discuss the host genetic factors, which have been under investigation in association with COVID-19 severity. We touch upon the intricate link between autoimmunity and COVID-19 pathophysiology. We put forth a number of autoimmune susceptibility genes, which have the potential to be additional host genetic factors for modifying the severity of COVID-19 presentation. In summary, host genetics at the intersection of ADs and COVID-19 may serve as a source for understanding the heterogeneity of COVID-19 severity, and hence, potentially holds a key in achieving effective strategies in risk group identification, as well as effective treatments.

【 授权许可】

Unknown