Chemical insights into the synthetic chemistry of five-membered saturated heterocycles—a transition metal–catalyzed approach

Frontiers in Chemistry

Chemistry

Mohib Ullah¹  Obaid-Ur-Rahman Abid²  Muhammad Alamzeb³  Muhammad Omer⁴  Ihsan Ullah⁴  Muhammad Sohail⁴ 

[1] Department of Chemistry, Balochistan University of Information Technology Engineering and Management Sciences (BUITEMS), Quetta, Pakistan;Department of Chemistry, Hazara University, Mansehra, Pakistan;Department of Chemistry, University of Kotli, Kotli, Pakistan;Institute of Chemical Sciences, University of Swat, Swat, Pakistan;

关键词: heterocycles;    saturated;    five-membered;    transition metals;    synthesis;    catalysis;    green;   

DOI  :  10.3389/fchem.2023.1185669

 received in 2023-04-13, accepted in 2023-07-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

Drug design and delivery is primarily based on the hunt for new potent drug candidates and novel synthetic techniques. Recently, saturated heterocycles have gained enormous attention in medicinal chemistry as evidenced by the medicinal drugs listed in the FDA Orange Book. Therefore, the demand for novel saturated heterocyclic syntheses has increased tremendously. Transition metal (TM)–catalyzed reactions have remained the prime priority in heterocyclic syntheses for the last three decades. Nowadays, TM catalysis is well adorned by combining it with other techniques such as bio- and/or enzyme-catalyzed reactions, organocatalysis, or using two different metals in a single catalysis. This review highlights the recent developments of the transition metal–catalyzed synthesis of five-membered saturated heterocycles.

【 授权许可】

Unknown   
Copyright © 2023 Sunbal, Alamzeb, Omer, Abid, Ullah, Sohail and Ullah.