Incorporation of acetate into fatty acids and lecithin by lung slices from fetal and newborn lambs

Journal of Lipid Research

Forrest H. Adams¹  Nobukazu Chida¹ 

[1] Division of Cardiology, Department of Pediatrics, University of California at Los Angeles School of Medicine, Los Angeles, California 90024;

关键词: incorporation;    acetate-1-14C;    lecithin;    saturated;    fatty acids;    lung;   

DOI  :  

来源: DOAJ

【 摘 要 】

Incorporation of acetate-1-14 into phospholipids and fatty acids by lung slices from fetal and newborn lambs and from ewes was studied in vitro. The distribution of radioactivity in the fatty acids of neutral lipids, phospholipids, and lecithin was determined. Acetate-1-14C was incorporated into myristic, palmitic, and C18 fatty acids. Of the lecithin fatty acids, myristic and palmitic were the major radioactive fatty acids.The results indicate that the lung of fetal lambs is able to synthesize lecithin containing saturated fatty acids, a major constituent of pulmonary surfactant. A marked increase in the rate of acetate incorporation into lecithin was observed during maturation, and these rates were higher than those obtained in the ewes. A possible relationship between developmental changes in lecithin biosynthesis and pulmonary surfactant is discussed.

【 授权许可】

Unknown