Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation

Fluids and Barriers of the CNS

Research

Bastian Zapf¹  Per Kristian Eide²  Geir Ringstad³  Marie E. Rognes⁴  Kent-Andre Mardal⁵  Vegard Vinje⁶ 

[1] Department of Mathematics, University of Oslo, Oslo, Norway;Department of Neurosurgery, Oslo University Hospital – Rikshospitalet, Oslo, Norway;Department of Radiology, Oslo University Hospital – Rikshospitalet, Oslo, Norway;Department of Geriatrics and Internal Medicine, Sørlandet Hospital, Arendal, Norway;Simula Research Laboratory, Kristian Augusts gate 23, 0164, Oslo, Norway;Simula Research Laboratory, Kristian Augusts gate 23, 0164, Oslo, Norway;Department of Mathematics, University of Oslo, Oslo, Norway;Simula Research Laboratory, Kristian Augusts gate 23, 0164, Oslo, Norway;Expert Analytics AS, Møllergata 8, 0179, Oslo, Norway;

关键词: CSF dynamics;    MRI tracer transport;    Glymphatic system;    Perivascular flow;    Sleep;   

DOI  :  10.1186/s12987-023-00459-8

 received in 2023-04-15, accepted in 2023-07-21,  发布年份 2023

来源: Springer

【 摘 要 】

Whether you are reading, running or sleeping, your brain and its fluid environment continuously interacts to distribute nutrients and clear metabolic waste. Yet, the precise mechanisms for solute transport within the human brain have remained hard to quantify using imaging techniques alone. From multi-modal human brain MRI data sets in sleeping and sleep-deprived subjects, we identify and quantify CSF tracer transport parameters using forward and inverse subject-specific computational modelling. Our findings support the notion that extracellular diffusion alone is not sufficient as a brain-wide tracer transport mechanism. Instead, we show that human MRI observations align well with transport by either by an effective diffusion coefficent 3.5×\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\times $$\end{document} that of extracellular diffusion in combination with local clearance rates corresponding to a tracer half-life of up to 5 h, or by extracellular diffusion augmented by advection with brain-wide average flow speeds on the order of 1–9 μ\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\mu $$\end{document}m/min. Reduced advection fully explains reduced tracer clearance after sleep-deprivation, supporting the role of sleep and sleep deprivation on human brain clearance.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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