Cardiovascular health profiles in adolescents being born term or preterm—results from the EVA-Tyrol study

BMC Cardiovascular Disorders

Research

Jean-Pierre Ndayisaba¹  Ursula Kiechl-Kohlendorfer²  Elke Griesmaier²  Christoph Hochmayr³  Nina Gande³  Anna Staudt³  Ralf Geiger⁴  Sophia J. Kiechl⁵  Michael Knoflach⁶  Benoit Bernar⁷  Katharina Stock⁸ 

[1] Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria;Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria;Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria;VASCage, Center on Clinical Stroke Research, Innsbruck, Tyrol, Austria;Department of Pediatrics III (Pediatric Cardiology, Allergology and Cystic Fibrosis), Medical University of Innsbruck, Innsbruck, Austria;VASCage, Center on Clinical Stroke Research, Innsbruck, Tyrol, Austria;Department of Neurology, Hochzirl Hospital, Zirl, Austria;VASCage, Center on Clinical Stroke Research, Innsbruck, Tyrol, Austria;Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria;VASCage, Center on Clinical Stroke Research, Innsbruck, Tyrol, Austria;Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria;VASCage, Center on Clinical Stroke Research, Innsbruck, Tyrol, Austria;Department of Pediatrics III (Pediatric Cardiology, Allergology and Cystic Fibrosis), Medical University of Innsbruck, Innsbruck, Austria;

关键词: Preterm birth;    Cardiovascular health;    Health metrics;    Risk factors;    Adolescents;    Health promotion;   

DOI  :  10.1186/s12872-023-03360-2

 received in 2023-02-22, accepted in 2023-06-21,  发布年份 2023

来源: Springer

【 摘 要 】

Background and aimsPreterm birth has been linked with an increased risk of cardiovascular (CV) disease from childhood into adolescence and early adulthood. In this study, we aimed to investigate differences in CV health profiles between former term- and preterm-born infants in a cohort of Tyrolean adolescents.MethodsThe Early Vascular Aging (EVA)-Tyrol study is a population-based non-randomized controlled trial, which prospectively enrolled 14- to 19-year-old adolescents in North Tyrol, Austria and South Tyrol, Italy between 2015 and 2018. Metrics of CV health (body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), smoking, physical activity, dietary patterns, total cholesterol and fasting blood glucose) were assessed and compared between former term- and preterm-born girls and boys.ResultsIn total, 1,491 study participants (59.5% female, mean age 16.5 years) were included in the present analysis. SBP and DBP were significantly higher in former preterm-born adolescents (mean gestational age 34.6 ± 2.4 weeks) compared to term-born controls (p < 0.01). In the multivariate regression analysis these findings remained significant after adjustment for potential confounders in all models. No differences were found in all other CV health metrics. The number of participants meeting criteria for all seven health metrics to be in an ideal range was generally very low with 1.5% in former term born vs. 0.9% in former preterm born adolescents (p = 0.583).ConclusionsPreterm birth is associated with elevated SBP and DBP in adolescence, which was even confirmed for former late preterm-born adolescents in our cohort. Our findings underscore the importance of promoting healthy lifestyles in former term- as well as preterm-born adolescents. In addition, we advise early screening for hypertension and long-term follow-up in the group of preterm-born individuals.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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