Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study

BMC Public Health

Research

Zhuo Chen¹  Lin Shi¹  Liang Zhang²  Dan Zhang³ 

[1] Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, Jiangsu, China;Department of Gastrointestinal Surgery, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou, Jiangsu, China;Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, 99 West Huai-hai Road, 221002, Xuzhou, Jiangsu, China;

关键词: Systemic immune-inflammation index;    Low muscle mass;    Population-based study;    NHANES;    Cross-sectional study;   

DOI  :  10.1186/s12889-023-16338-8

 received in 2023-01-20, accepted in 2023-07-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundChronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose of our study was to clarify the relationship between SII and low muscle mass.MethodsThis study was a cross-sectional study based on National Health and Nutrition Examination Survey (2011–2018). SII was calculated as the platelet count × neutrophil count/lymphocyte count. Appendicular skeletal muscle index was used to define low muscle mass. The individuals were divided into four groups by the quartile of SII (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting and subgroup analysis were used to investigate the relationship between SII and sarcopenia. Subgroup analysis were based on demographic and clinical variables.ResultsThere were 10,367 individuals enrolled in our final analysis. The overall mean age was 39.39 years and 49.17% were males. The overall prevalence of low muscle mass in the study population was 8.77%. The smooth curve fitting analysis indicated a near-linear relationship between SII and low muscle mass. In multivariate weighted logistic regression analysis, the odds ratio (OR) of Q4 is 1.28 (95% CI, 1.16–1.40) for low muscle mass when compared to lowest quartile of the SII. In subgroup analysis, SII still increased the risk of low muscle mass independently.ConclusionThe increased SII levels were associated with an increased risk of low muscle mass in a large population. Our study increased the understanding between inflammation and low muscle mass. Anti-inflammation therapy may be important for low muscle mass.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5