Association between systemic immune-inflammation index and chronic obstructive pulmonary disease: a population-based study

BMC Pulmonary Medicine

Research

Li Yuan¹  Chengliang Zhu²  Chenglin Ye²  Bingzheng Shen³  Kailang Wu⁴ 

[1] Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, 430060, Wuhan, Hubei, PR China;Department of Clinical Laboratory, institute of translational medicine, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, PR China;Department of Pharmacy, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei, PR China;State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 430072, Wuhan, Hubei, PR China;

关键词: NHANES;    Chronic obstructive pulmonary disease;    Cross-sectional study;    Population-based study;    Systemic immune-inflammation index;   

DOI  :  10.1186/s12890-023-02583-5

 received in 2023-04-11, accepted in 2023-07-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe Systemic Immune-Inflammation Index (SII) is a quantitative measurement of the systemic immune-inflammatory response in the human body. The SII has been shown to have prognostic value in various clinical settings, including critical illness, sepsis, and cancer. Its role in chronic obstructive pulmonary disease (COPD) remains unclear and requires further investigation.MethodsWe analyzed demographic data from 16,636 participants in the National Health and Nutrition Examination Survey. Logistic regression analysis was performed to assess the correlation between COPD, lung function, chronic respiratory symptoms and SII. We used Cox proportional hazards (PH) model to analyze the relationship between SII and mortality in COPD patients and healthy individuals. We used propensity score matching (PSM) method to match the COPD population with similar baseline levels with the normal population to further analyze the correlation between SII and COPD.ResultsWe recruited 16,636 participants, ages 40 and above, for the study. A multivariable logistic regression analysis revealed that a higher SII level was independently associated with an elevated likelihood of COPD (Odds Ratio (OR) = 1.449; 95% Confidence Interval (CI): 1.252–1.676, P < 0.0001) after controlling for all other factors. Results of subgroup analysis showed a significant positive correlation between SII and COPD in different age groups, gender, Body Mass Index, smoking status, and those with a history of hypertension. The SII index had positive correlation with COPD after PSM (OR = 1.673; 95%CI: 1.443–1.938). After full adjustment, an increase in the SII is associated with a higher all-cause mortality rate. The hazard ratio (HR) with a 95% CI in the general population, COPD patients, and healthy individuals are 1.161 (1.088, 1.239), 1.282 (1.060, 1.550), and 1.129 (1.055, 1.207), respectively.ConclusionsHigher SII levels are linked to higher prevalence of COPD. COPD patients with a higher SII levels have a higher risk of all-cause mortality. Additional large-scale, long-term studies are necessary to confirm these results.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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