Analysis of the relationship between sleep-related disorder and systemic immune-inflammation index in the US population

BMC Psychiatry

Research

Gulinazi Yesitayi¹  Xiang Ma¹  Kaisaierjiang Kadier¹  Mierxiati Ainiwan¹  Pengfei Liu¹  Aikeliyaer Ainiwaer¹  Yitong Ma¹  Xiaozhu Liu²  Jiande Lu³  Diliyaer Dilixiati³ 

[1] Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, China;Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;Department of Urology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;

关键词: Systemic immune-inflammation index;    Sleep-related disorder;    Obstructive sleep apnoea;    Daytime sleepiness;    Sleep problems;    Sleep duration;    NHANES;   

DOI  :  10.1186/s12888-023-05286-7

 received in 2023-03-21, accepted in 2023-10-16,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe association between sleep-related disorders and inflammation has been demonstrated in previous studies. The systemic immune-inflammation index (SII) is a novel inflammatory index based on leukocytes, but its relationship with sleep-related disorder is unclear. We aimed to investigate the relationship between sleep-related disorder and SII in a nationally representative nonhospitalized sample.MethodsData were obtained from the 2005–2008 National Health and Nutrition Examination Survey (NHANES). Exposure variables included self-reported sleep-related disorders, such as sleep duration, sleep problems, high risk of OSA, and daytime sleepiness. SII and other traditional markers of inflammation were considered as outcome variables, including platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR). Multiple linear regression models were employed to examine the correlation between sleep-related disorders and inflammatory markers. Subgroup interactions were analyzed using likelihood ratio tests, and nonlinear relationships were explored by fitting restricted cubic splines.ResultsA total of 8,505 participants were enrolled in this study. Overall, sleep-related disorders were found to have a stronger association with SII compared to the PLR and NLR. The results of multiple linear regression analysis revealed that participants who experienced sleep problems (β: 21.421; 95% CI 1.484, 41.358), had symptoms of OSA (β: 23.088; 95% CI 0.441, 45.735), and reported daytime sleepiness (β: 30.320; 95% CI 5.851, 54.789) exhibited a positive association with higher SII. For the analysis of other inflammatory markers, we only found that daytime sleepiness was associated with increased NLR levels (β: 0.081; 95% CI 0.002, 0.159).ConclusionSleep problems, symptoms of OSA, and daytime sleepiness were found to have a positive association with the SII in US adults. However, further prospective studies are necessary to establish whether there is a causal relationship between these factors.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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