DHA supplementation and pregnancy complications

Journal of Translational Medicine

Review

Yuting Chen¹  Xuan Zhou²  Yuanyuan Du²  Lijie Wei²  Wencheng Ding²  Jingyi Zhang²  Rui Su²  Chenyun Fang²  Huiting Zhang²  Yi Jiang²  Shenglan Zhu²  Ling Feng² 

[1] Department of Obstetrics and Gynecology Ultrasound, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China;Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Avenue, 430030, Wuhan, Hubei, China;

关键词: Docosahexaenoic acid;    Pregnancy;    Preeclampsia;    Gestational diabetes mellitus;    Preterm birth;    Intrauterine growth restriction;    Postpartum depression;    Neuroprotection;   

DOI  :  10.1186/s12967-023-04239-8

 received in 2023-03-02, accepted in 2023-05-31,  发布年份 2023

来源: Springer

【 摘 要 】

Docosahexaenoic acid (DHA) supplementation is recommended for women during pregnancy because of its neurological, visual, and cognitive effects. Previous studies have suggested that DHA supplementation during pregnancy may prevent and treat certain pregnancy complications. However, there are contradictions in the current related studies, and the specific mechanism by which DHA acts remains unclear. This review summarizes the research on the relationship between DHA intake during pregnancy and preeclampsia, gestational diabetes mellitus, preterm birth, intrauterine growth restriction, and postpartum depression. Furthermore, we explore the impact of DHA intake during pregnancy on the prediction, prevention, and treatment of pregnancy complications as well as its impact on offspring neurodevelopment. Our results suggest that there is limited and controversial evidence for the protective effect of DHA intake on pregnancy complications, with the exception of preterm birth and gestational diabetes mellitus. However, additional DHA supplementation may improve long-term neurodevelopmental outcomes in the offspring of women with pregnancy complications.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1