A hydrogel-based first-aid tissue adhesive with effective hemostasis and anti-bacteria for trauma emergency management

Biomaterials Research

Research Article

Yun Lu¹  Dongjie Zhang¹  Jilin Hu¹  Yaodong Zhao²  Xuewei Li³  Yuanping Hao⁴  Yongzhi Xu⁴  Xuyang Deng⁵  Hailin Huang⁵  Cong Li⁵  Zhe Wang⁵  Danyang Wang⁵  Li Mei⁵  Bingcheng Yi⁶  Qihui Zhou⁷ 

[1] Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266003, Qingdao, China;Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266003, Qingdao, China;Department of Stomatology, Qingdao University, 266021, Qingdao, China;Department of Hematology, The Affiliated Hospital of Qingdao University, 266003, Qingdao, China;Department of Stomatology, Qingdao Stomatological Hospital Affiliated to Qingdao University, 266003, Qingdao, China;Department of Stomatology, Qingdao University, 266021, Qingdao, China;School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, 266071, Qingdao, China;School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, 266071, Qingdao, China;Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, 325000, Wenzhou, Zhejiang, China;

关键词: Tissue adhesive;    Self-healing;    Anti-infection;    Hydrogel;    Carboxymethyl chitosan;    Trauma emergency;   

DOI  :  10.1186/s40824-023-00392-9

 received in 2023-02-16, accepted in 2023-05-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundClinical tissue adhesives remain some critical drawbacks for managing emergency injuries, such as inadequate adhesive strength and insufficient anti-infection ability. Herein, a novel, self-healing, and antibacterial carboxymethyl chitosan/polyaldehyde dextran (CMCS/PD) hydrogel is designed as the first-aid tissue adhesive for effective trauma emergency management.MethodsWe examined the gel-forming time, porosity, self-healing, antibacterial properties, cytotoxicity, adhesive strength, and hemocompatibility. Liver hemorrhage, tail severance, and skin wound infection models of rats are constructed in vivo, respectively.ResultsResults demonstrate that the CMCS/PD hydrogel has the rapid gel-forming (~ 5 s), good self-healing, and effective antibacterial abilities, and could adhere to tissue firmly (adhesive strength of ~ 10 kPa and burst pressure of 327.5 mmHg) with excellent hemocompatibility and cytocompatibility. This suggests the great prospect of CMCS/PD hydrogel in acting as a first-aid tissue adhesive for trauma emergency management. The CMCS/PD hydrogel is observed to not only achieve rapid hemostasis for curing liver hemorrhage and tail severance in comparison to commercial hemostatic gel (Surgiflo ®) but also exhibit superior anti-infection for treating acute skin trauma compared with clinical disinfectant gel (Prontosan ®).ConclusionsOverall, the CMCS/PD hydrogel offers a promising candidate for first-aid tissue adhesives to manage the trauma emergency. Because of the rapid gel-forming time, it could also be applied as a liquid first-aid bandage for mini-invasive surgical treatment.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 1