Mesenchymal stromal cell-derived secretome-based therapy for neurodegenerative diseases: overview of clinical trials

Stem Cell Research & Therapy

Review

Behrouz Farhadihosseinabadi¹  Mozhdeh Mohammadian²  Elham Roshandel³  Parvin Akbarzadehlaleh⁴  Karim Shamsasenjan⁵  Maryam Ghasemi⁶ 

[1] Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran;Department of Hematology, School of Medicine, Tarbiat Modares University (TMU), Tehran, Iran;Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Pharmaceutical Biotechnology Department, Pharmacy Faculty, Tabriz University of Medical Science, Tabriz, Iran;Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Mesenchymal stem cell;    Secretome;    Culture media;    Exosomes;    Neurodegenerative disorders;    Cell-free therapy;   

DOI  :  10.1186/s13287-023-03264-0

 received in 2022-06-19, accepted in 2023-03-06,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundOver the past few years, mesenchymal stromal cells (MSCs) have attracted a great deal of scientific attention owing to their promising results in the treatment of incurable diseases. However, there are several concerns about their possible side effects after direct cell transplantation, including host immune response, time-consuming cell culture procedures, and the dependence of cell quality on the donor, which limit the application of MSCs in clinical trials. On the other hand, it is well accepted that the beneficial effects of MSCs are mediated by secretome rather than cell replacement. MSC secretome refers to a variety of bioactive molecules involved in different biological processes, specifically neuro-regeneration.Main bodyDue to the limited ability of the central nervous system to compensate for neuronal loss and relieve disease progress, mesenchymal stem cell products may be used as a potential cure for central nervous system disorders. In the present study, the therapeutic effects of MSC secretome were reviewed and discussed the possible mechanisms in the three most prevalent central nervous system disorders, namely Alzheimer's disease, multiple sclerosis, and Parkinson's disease. The current work aimed to help discover new medicine for the mentioned complications.ConclusionThe use of MSC-derived secretomes in the treatment of the mentioned diseases has encouraging results, so it can be considered as a treatment option for which no treatment has been introduced so far.

【 授权许可】

CC BY   
© The Author(s) 2023

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