Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

Biomarker Research

Correspondence

Ann-Kristin Reinhold¹  Heike L. Rittner¹  Oliver Scherf-Clavel²  K. Martin Kortüm³  Maximilian J. Steinhardt³  Eva Teufel³  Julia Mersi³  Xiang Zhou³  Emilia Stanojkovska³  Hermann Einsele³  Umair Munawar³  Seungbin Han³  Cornelia Vogt³  Silvia Nerreter³  Leo Rasche³  Larissa Haertle⁴  Calvin Terhorst⁵  Robert Blum⁵  Claudia Sommer⁵  Nadine Cebulla⁵  Laura Jähnel⁵  Eva Runau⁵  Leon Flamm⁵  Daniel Schirmer⁵  Mirko Pham⁶  Magnus Schindehütte⁶ 

[1]Center for Interdisciplinary Medicine, Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital of Würzburg, Würzburg, Germany

[2]Department of Clinical Pharmacy, University of Würzburg, Würzburg, Germany

[3]Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany

[4]Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany

[5]Department of Hematology, Spanish National Cancer Research Center (CNIO), Hospital Universitario 12 de Octubre, Complutense University Madrid, Madrid, Spain

[6]Department of Neurology, University Hospital of Würzburg, Würzburg, Germany

[7]Department of Neuroradiology, University Hospital of Würzburg, Würzburg, Germany

关键词: PKNOX1;    Multiple myeloma;    Bortezomib;    Peripheral neuropathy;   

DOI  :  10.1186/s40364-023-00490-9

 received in 2023-02-07, accepted in 2023-04-20,  发布年份 2023

来源: Springer

【 摘 要 】

We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were significantly enriched in patients with painful peripheral neuropathy (PNP) (P < 0.0001), and homozygous mutated rs2839629 genotype was significantly enriched in patients with pain compared to patients with no pain (P = 0.04). In summary, both SNPs rs2839629 and/or rs915854 may be potential biomarkers predicting an increased risk to develop painful PNP under bortezomib.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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