Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy

Experimental Hematology & Oncology

Yubin Kang²  Ashley Jeter¹ 

[1] Division of Hematology and Oncology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA;Hollings Cancer Center, 86 Jonathan Lucas Street, Room# HO307, Charleston, SC, 29425, USA

关键词: Multiple myeloma;    Immune modulation;    Peripheral neuropathy;    Bortezomib;   

Others  :  814730
DOI  :  10.1186/2162-3619-1-20

 received in 2012-06-29, accepted in 2012-08-09,  发布年份 2012

【 摘 要 】

Peripheral neuropathy (PN) is one of the most common side effects of bortezomib therapy. The majority of bortezomib-related PN is a sensory neuropathy of mild to moderate degree, and is reversible after dose reduction or discontinuation. However, occasionally bortezomib-induced neuropathy can be severe and affects motor and/or autonomic nerves, and may be mediated by immune process. The role of immune modulation therapy in the management of bortezomib-induced PN was not well established. Here, we reported a case of bortezomib-induced severe PN that responded well to plasma exchange and steroid treatment.

【 授权许可】

   
2012 Jeter and Kang; licensee BioMed Central Ltd.

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