Experimental Hematology & Oncology | |
Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy | |
关键词: Bortezomib; Peripheral neuropathy; Immune modulation; Multiple myeloma; | |
DOI : 10.1186/2162-3619-1-20 | |
来源: DOAJ |
【 摘 要 】
Abstract
Peripheral neuropathy (PN) is one of the most common side effects of bortezomib therapy. The majority of bortezomib-related PN is a sensory neuropathy of mild to moderate degree, and is reversible after dose reduction or discontinuation. However, occasionally bortezomib-induced neuropathy can be severe and affects motor and/or autonomic nerves, and may be mediated by immune process. The role of immune modulation therapy in the management of bortezomib-induced PN was not well established. Here, we reported a case of bortezomib-induced severe PN that responded well to plasma exchange and steroid treatment.
【 授权许可】
Unknown