The influence of protein fractions and electrolyte imbalance on refractive index of serum in patients with multiple myeloma

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Plotnikova, L.^1 ; Polyanichko, A.^2 ; Kobeleva, M.^1 ; Uspenskaya, M.^1 ; Garifullin, A.^3 ; Voloshin, S.^3

Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Kronveksky pr. 49, Saint-Petersburg

197101, Russia^1

Saint Petersburg State University, Universitetskaya Nab. 7/9, Saint-Petersburg

199034, Russia^2

Russian Scientific Research Institute of Hematology and Transfusiology, 2nd Sovetskaya str. 16, Saint-Petersburg

191024, Russia^3

关键词: Biological liquids;    Electrolyte imbalance;    Low molecular weight compounds;    Multiple myeloma;    Protein concentrations;    Protein fractions;    Solids concentrations;    Strong correlation;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012047/pdf
DOI  :  10.1088/1742-6596/784/1/012047

来源: IOP

【 摘 要 】

Refractometric analysis is very rapid, accurate and simple method of analysis measuring refractive index of biological liquids such as serum, plasma, spinal fluid, urine. This method can be used for definition total protein and solids concentrations in serum. The value of refractive index depends on all substances in serum including proteins, lipids as well as low molecular weight compounds, for example ions of different metals. Refractometric analysis shows strong correlations between protein concentrations in serum of patients with multiple myeloma and its(serum) refractive index which depends on protein concentration and doesn't depends on electrolyte disbalance.