Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects

Nanotheranostics

article

Xiaoxuan Zhang¹  Helin Xing³  Feng Qi⁴  Hongchen Liu⁵  Lizeng Gao⁶  Xing Wang¹ 

[1] Shanxi Medical University School and Hospital of Stomatology;Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials;Department of Prosthodontics, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University;Department of Mechanical and Aerospace Engineering, University of Missouri;Institute of Stomatology & Oral Maxilla Facial Key Laboratory, Chinese PLA General Hospital;CAS Engineering Laboratory for Nanozyme, Institute of Biophysics, Chinese Academy of Sciences

关键词: Nanoparticles;    Insulin;    Insulin-like growth factor;    Bone regeneration;    Angiogenesis;    Osteogenesis;   

DOI  :  10.7150/ntno.46408

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Bone defects caused by trauma, tumor resection, congenital malformation and infection are still a major challenge for clinicians. Biomimetic bone materials have attracted more and more attention in science and industry. Insulin and insulin-like growth factor-1 (IGF-1) have been increasingly recognized as an inducible factor for osteogenesis and angiogenesis. Spatiotemporal release of insulin may serve as the promising strategy. Considering the successful application of nanoparticles in drug loading, various insulin delivery systems have been developed, including (poly (lactic-co-glycolic acid), PLGA), hydroxyapatite (HA), gelatin, chitosan, alginate, and (γ-glutamic acid)/β-tricalcium phosphate, γ-PGA/β-TCP). Here, we have reviewed the progress on nanoparticles carrying insulin/IGF for bone regeneration. In addition, the key regulatory mechanism of insulin in bone regeneration is also summarized. The future application strategies and the challenges in bone regeneration are also discussed.

【 授权许可】

CC BY-NC