Specific binding of human growth hormone but not insulin‐like growth factors by human adipocytes

FEBS Letters

Hall, Kerstin¹  DiGirolamo, Mario¹  Edén, Staffan¹  Isaksson, Olle¹  Enberg, Gösta¹  Smith, Ulf¹  Lönnroth, Peter¹ 

[1] Departments of Medicine II, University of Gothenburg, GothenburgSweden

关键词: Growth hormone;    Insulin;    Insulin-like growth factor;    Adipocyte;   

DOI  :  10.1016/0014-5793(86)80856-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Binding of human GH (hGH) and insulin-like growth factors I and II (IGFI and II) to isolated human adipocytes from adult subjects was studied. Binding equilibrium for hGH at 24°C was reached at 120 min and half-maximal specific binding at 6–8 . Apparent K _a was 2.1 × 10⁹ M⁻¹ and B _max 7.3 × 10⁻¹¹ M/10⁶ cells. The human fat cellgrowth hormone receptor recognized neither bovine, ovine or rat GH nor human prolactin or placental lactogen. No specific receptors for human IGFII could be demonstrated. Thus, human adipocytes do not possess IGF receptors but have specific GH receptors which recognize hGH but not GH from lower species.

【 授权许可】

Unknown