Protective effects of the extracts of Barringtonia racemosa shoots against oxidative damage in HepG2 cells

PeerJ

article

Kin Weng Kong¹  Sarni Mat-Junit¹  Norhaniza Aminudin²  Fouad Abdulrahman Hassan³  Amin Ismail³  Azlina Abdul Aziz¹ 

[1] Department of Molecular Medicine, Faculty of Medicine, University of Malaya;Institute of Biological Sciences, Faculty of Science, University of Malaya;Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia

关键词: Polyphenols;    Barringtonia racemosa;    HPLC-ESI-MS;    Antioxidant enzymes;    Lipid peroxidation;    Oxidative stress;   

DOI  :  10.7717/peerj.1628

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Barringtonia racemosa80%) at concentration less than 250 µg/ml and 500 µg/ml, respectively. BLE and BSE improved cellular antioxidant status measured by FRAP assay and protected HepG2 cells against H2O2-induced cytotoxicity. The extracts also inhibited lipid peroxidation in HepG2 cells as well as the production of reactive oxygen species. BLE and BSE could also suppress the activities of superoxide dismutase and catalase during oxidative stress. The shoots of B. racemosa can be an alternative bioactive ingredient in the prevention of oxidative damage.

【 授权许可】

CC BY