期刊论文详细信息
PeerJ
Compositional distinction of gut microbiota between Han Chinese and Tibetan populations with liver cirrhosis
article
Hui Huan1  Tao Ren1  Li Xu1  Hong Hu1  Chao Liu1 
[1] Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region
关键词: Tibetan population;    Liver cirrhosis;    Gut microbiota;    16S rRNA gene sequencing;   
DOI  :  10.7717/peerj.12142
学科分类:社会科学、人文和艺术(综合)
来源: Inra
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【 摘 要 】

Background Liver cirrhosis (LC) is caused by numerous chronic liver diseases and its complications are associated with qualitative and quantitative alterations of the gut microbiota. Previous studies have revealed the characteristics of gut microbiota in Han Chinese patients with LC and different compositions of gut microbiota were reported between the Tibetan and Han Chinese populations. This study was designed to evaluate the unique features of the gut microbiota of Tibetans and compare the differences of gut microbiota between Tibetan and Han Chinese patients with LC. Methods Thirty-six patients with liver cirrhosis and nineteen healthy volunteers, from both Tibetan and Han Chinese populations, were enrolled and fecal samples were collected for 16S rRNA gene sequencing analyses. Results Significant differences were found in the gut microbiota of healthy volunteers and between Tibetan and Han Chinese patients with LC. In the Han Chinese patients with cirrhosis (HLC) group the relative abundances of the phylum Bacteroidetes was significantly reduced (P < 0.001), whereas in the Tibetan patients with cirrhosis (TLC) group Firmicutes and Actinobacteria were highly enriched (P = 0.01 and 0.03, respectively). At the genus level, the relative abundances of Anaerostipes (P < 0.001), Bifidobacterium (P = 0.03), and Blautia (P = 0.004) were prevalent, while Alloprevotella, Dorea, Prevotella_2, Prevotella_7 and Prevotella_9 were decreased in the TLC group compared to the HLC group (P < 0.01). Conclusion Our findings showed how the intestinal bacterial community shifted in Tibetan patients with cirrhosis.

【 授权许可】

CC BY   

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