The expanding roles of neuronal nitric oxide synthase (NOS1)

PeerJ

article

Kundan Solanki¹  Sajjan Rajpoot¹  Evgeny E. Bezsonov²  Alexander N. Orekhov²  Rohit Saluja⁵  Anita Wary⁶  Cassondra Axen⁶  Kishore Wary⁶  Mirza S. Baig¹ 

[1] Department of Biosciences and Biomedical Engineering ,(BSBE), Indian Institute of Technology Indore;Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”;Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology;Department of Biology and General Genetics, I.M. Sechenov First Moscow State Medical University ,(Sechenov University);Department of Biochemistry, All India Institute of Medical Sciences;Pharmacology and Regenerative Medicine, University of Illinois at Chicago

关键词: Nitric oxide synthase;    Nitric oxide;    Epigenetics;    Transcriptional regulation;    Vasodilation;    Nitric oxide signaling;    Cancer;    Diabetes;    Cardiovascular;    Redox;   

DOI  :  10.7717/peerj.13651

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

The nitric oxide synthases (NOS; EC 1.14.13.39) use L-arginine as a substrate to produce nitric oxide (NO) as a by-product in the tissue microenvironment. NOS1 represents the predominant NO-producing enzyme highly enriched in the brain and known to mediate multiple functions, ranging from learning and memory development to maintaining synaptic plasticity and neuronal development, Alzheimer’s disease (AD), psychiatric disorders and behavioral deficits. However, accumulating evidence indicate both canonical and non-canonical roles of NOS1-derived NO in several other tissues and chronic diseases. A better understanding of NOS1-derived NO signaling, and identification and characterization of NO-metabolites in non-neuronal tissues could become useful in diagnosis and prognosis of diseases associated with NOS1 expression. Continued investigation on the roles of NOS1, therefore, will synthesize new knowledge and aid in the discovery of small molecules which could be used to titrate the activities of NOS1-derived NO signaling and NO-metabolites. Here, we address the significance of NOS1 and its byproduct NO in modifying pathophysiological events, which could be beneficial in understanding both the disease mechanisms and therapeutics.

【 授权许可】

CC BY