Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant

PeerJ

article

Lina Zhang¹  Shucai Xie¹  Feng Lyu⁴  Chun Liu⁵  Chunhui Li³  Wei Liu¹  Xinhua Ma¹  Jieyu Zhou⁴  Xinyu Qian⁴  Yong Lu⁷  Zhaoxin Qian¹ 

[1] Department of Critical Care Medicine, Xiangya Hospital, Central South University;Hunan Provincial Clinical Research Center for Critical Care Medicine;National Clinical Research Center for Geriatric Disorders ,(Xiangya Hospital), Xiangya Hospital, Central South University;School of Computer Science and Engineering, Central South University;Respiratory and Critical Care Medicine Department, The Third Xiangya Hospital of Central South University;Xiangya Hospital, Central South University;Department of Radiology, Ruijin Hospital Luwan Branch, School of Medicine, Shanghai Jiaotong University

关键词: Omicron;    COVID-19;    Viral clearance;    Immunoglobulin G;    Activated partial thromboplastin time;    Platelet;    Indirect bilirubin;   

DOI  :  10.7717/peerj.15443

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

Background Omicron is the recently emerged highly transmissible severe acute respiratory syndrome coronavirus 2 variant that has caused a dramatic increase in coronavirus disease-2019 infection cases worldwide. This study was to investigate the association between demographic and laboratory findings, and the duration of Omicron viral clearance. Methods Approximately 278 Omicron cases at the Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine were retrospectively analyzed between August 11 and August 31, 2022. Demographic and laboratory data were also collected. The association between demographics, laboratory findings, and duration of Omicron viral clearance was analyzed using Pearson correlation analysis and univariate and multivariate logistic regression. Results Univariate logistic regression analyses showed that a prolonged viral clearance time was significantly associated with older age and lower immunoglobulin (Ig) G and platelet (PLT) levels. Using multinomial logistic regression analyses, direct bilirubin, IgG, activated partial thromboplastin time (APTT), and PLT were independent factors for longer viral shedding duration. The model combining direct bilirubin, IgG, APTT, and PLT identifies patients infected with Omicron whose viral clearance time was ≥7 days with 62.7% sensitivity and 83.4% specificity. Conclusion These findings suggest that direct bilirubin, IgG, PLT, and APTT are significant risk factors for a longer viral shedding duration in patients infected with Omicron. Measuring levels of direct bilirubin, IgG, PLT, and APTT is advantageous to identify patients infected with Omicron with longer viral shedding duration.

【 授权许可】

CC BY