Risk factors associated with prolonged viral clearance in patients with a refractory course of COVID-19: a retrospective study

PeerJ

article

Weitao Zhuang¹  Shujie Huang¹  Dongya Wang³  Lulu Zha⁴  Wei Xu⁶  Guibin Qiao¹ 

[1] Department of Thoracic Surgery, Guangdong Provincial People’s Hospital;Shantou University Medical College;Department of Hyperbaric Oxygen and Rehabilitation, General Hospital of Southern Theater Command;The Fifth Department of Infectious Diseases, Huoshenshan Hospital;Department of Nursing, General Hospital of Southern Theater Command;School of Public Health and Management, Chongqing Medical University

关键词: COVID-19;    Reinfection;    Refractory;    Viral clearance;    Risk factors;   

DOI  :  10.7717/peerj.12535

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundThis study aimed to characterize a cohort of patients with a refractory course of COVID-19, and to investigate factors associated with the duration of viral clearance (DoVC).Materials & MethodsA total of 65 patients with refractory COVID-19 were retrospectively enrolled from Huoshenshan Hospital. Univariate analysis and multivariate analysis were performed to examine the potential association between clinicopathologic characteristics and the DoVC.ResultsThe median DoVC in the overall study cohort was 48 days (ranged from 21 to 104 days). Multivariate analysis indicated that fever at illness onset (Hazard ratio (HR) = 4.897, 95% CI [1.809–13.260], p 142.09 AU/ml (HR = 3.061, 95% CI [1.263–7.415], p = 0.013) were the three independent risk factors associated with delayed viral clearance.ConclusionThe current study suggested that clinical characteristics such as fever at illness onset, a high serum level of AST or SARS-CoV-2 IgG were associated with delayed viral clearance. Patients with these characteristics might need a more individualized treatment strategy to accelerate their recovery from the refractory COVID-19.

【 授权许可】

CC BY