OID-03. Arranging bone marrow donor registry in Sakha Republic (Yakutia)

Cellular Therapy and Transplantation

article

Vilena V. Gerasimova¹  Nadezhda V. Savvina²  Aitalina S. Golderova² 

[1] State Budgetary Institution of the Republic of Sakha ,(Yakutia) “Blood Transfusion Station”;M. K. Ammosov North-Eastern Federal University

关键词: Registry;    donors;    bone marrow;    Republic of Sakha (Yakutia).;   

DOI  :  10.18620/ctt-1866-8836-2022-11-3-1-132

学科分类：肿瘤学

来源: Universitaetsklinikum Hamburg - Eppendorf / University Medical Center Hamburg - Eppendorf

【 摘 要 】

As multinational Russian population consists of people with vastly different HLA phenotypes, the bone marrow donors’ registry should include as many donors from local populations as possible. Each year Republic of Sakha, Yakutia (RS, Y) 5-6 adults and 2-3 pediatric candidates for hematopoietic stem cell transplantation (HSCT) are registered by hematologists, and the number of patients with hematopoietic and solid tumors potentially requiring transplant gradually increase. The HLA alleles frequencies in Yakutia differ significantly from those observed in most donors from Russian population (Fefelova V.V., 2015]. However, this data may help to form a Registry for potential unrelated donors based on HLA combinations most often seen in HSCT recipients from Yakutia making the matched donor occurrence more probable. While general probability of donor selection in overall Russian Federation registry is 1 in 50000, the national Registry provides 1 potential donor in 5000.

【 授权许可】

CC BY