Noncoding RNAs in apoptosis: identification and function

Turkish Journal of Biology

article

TÜNCEL, ÖZGE¹  KARA, MERVE¹  YAYLAK, BİLGE¹  ERDOĞAN, İPEK¹  AKGÜL, BÜNYAMİN¹ 

[1]Non-coding RNA Laboratory, Department of Molecular Biology and Genetics, Faculty of Science,İzmir Institute of Technology

关键词: Apoptosis;    noncoding RNA;    microRNA;    long noncoding RNA;    circular RNA;   

DOI  :  10.3906/biy-2109-35

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

Apoptosis is a vital cellular process that is critical for the maintenance of homeostasis in health and disease. The derailment of apoptotic mechanisms has severe consequences such as abnormal development, cancer, and neurodegenerative diseases. Thus, there exist complex regulatory mechanisms in eukaryotes to preserve the balance between cell growth and cell death. Initially, protein-coding genes were prioritized in the search for such regulatory macromolecules involved in the regulation of apoptosis. However, recent genome annotations and transcriptomics studies have uncovered a plethora of regulatory noncoding RNAs that have the ability to modulate not only apoptosis but also many other biochemical processes in eukaryotes. In this review article, we will cover a brief summary of apoptosis and detection methods followed by an extensive discussion on microRNAs, circular RNAs, and long noncoding RNAs in apoptosis.

【 授权许可】

Unknown