Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer

Biomedicines

MunGyu Song¹  BaDa Yun¹  SeungWan Son¹  JongKook Park¹ 

[1] Department of Biomedical Science, Hallym University, Chunchon 24252, Korea;

关键词: noncoding RNA;    microRNA;    long noncoding RNA;    circular RNA;    therapeutic resistance;    pancreatic cancer;   

DOI  :  10.3390/biomedicines9030263

来源: DOAJ

【 摘 要 】

Therapeutic resistance is an inevitable impediment towards effective cancer therapies. Evidence accumulated has shown that the signaling pathways and related factors are fundamentally responsible for therapeutic resistance via regulating diverse cellular events, such as epithelial-to-mesenchymal transition (EMT), stemness, cell survival/apoptosis, autophagy, etcetera. Noncoding RNAs (ncRNAs) have been identified as essential cellular components in gene regulation. The expression of ncRNAs is altered in cancer, and dysregulated ncRNAs participate in gene regulatory networks in pathological contexts. An in-depth understanding of molecular mechanisms underlying the modulation of therapeutic resistance is required to refine therapeutic benefits. This review presents an overview of the recent evidence concerning the role of human ncRNAs in therapeutic resistance, together with the feasibility of ncRNAs as therapeutic targets in pancreatic cancer.

【 授权许可】

Unknown