Epidermal Stem Cells and Their Epigenetic Regulation

International Journal of Molecular Sciences

Qi Shen¹  Hongchuan Jin¹ 

[1] Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China;

关键词: epidermal stem cell;    epigenetic modification;    histone methylation;    DNA methylation;    noncoding RNA;    microRNA;    long noncoding RNA;   

DOI  :  10.3390/ijms140917861

来源: mdpi

【 摘 要 】

Stem cells play an essential role in embryonic development, cell differentiation and tissue regeneration. Tissue homeostasis in adults is maintained by adult stem cells resident in the niches of different tissues. As one kind of adult stem cell, epidermal stem cells have the potential to generate diversified types of progeny cells in the skin. Although its biology is still largely unclarified, epidermal stem cells are widely used in stem cell research and regenerative medicine given its easy accessibility and pluripotency. Despite the same genome, cells within an organism have different fates due to the epigenetic regulation of gene expression. In this review, we will briefly discuss the current understanding of epigenetic modulation in epidermal stem cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland