Epidemiology of Nosocomial Candidemia, Mortality, and Antifungal Resistance: 7-Year Experience in Turkey

Japanese journal of infectious diseases

article

Selda Aydin¹  Okan Derin²  Meyha Sahin¹  Rumeysa Dinleyici³  Mesut Yilmaz¹  Bahadır Ceylan¹  Ayse Istanbullu Tosun⁴  Recep Ozturk¹  Ali Mert⁵ 

[1] Department of Infectious Diseases and Clinical Microbiology, School of Medicine, Istanbul Medipol University;Department of Infectious Diseases and Clinical Microbiology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences;Department of Clinical Pharmacy, School of Pharmacy, Istanbul Medipol University;Department of Medical Microbiology, School of Medicine, Istanbul Medipol University;Department of Internal Medicine, School of Medicine, Istanbul Medipol University

关键词: candidemia;    nosocomial infections;    epidemiology;    Candida species;    antifungal resistance;   

DOI  :  10.7883/yoken.JJID.2022.181

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Candidemia is an important clinical condition that prolongs hospital stays and increases morbidity, mortality, and hospital costs. The aim of this retrospective study was to evaluate the epidemiological and microbiological characteristics of patients with candidemia between January 2013 and December 2019. Two hundred forty-one episodes of candidemia were observed in 230 patients, 45% of whom were female. The median age was 63 years, and 53.9% of the episodes were in the intensive care unit (ICU). Commonly observed predisposing factors for candidemia included antibiotic use (71.3%), urinary catheterization (56.3%), central venous catheter placement (50.3%), total parenteral nutrition (47.9%), solid-organ malignancy (46%), surgery (48.6%), chemotherapy (37%), and steroid treatment (25.5%). The crude mortality rate was 52.7%. A significant difference was found between survivors and non-survivors (P = 0.007) according to the Charlson Comorbidity Index. However, no statistically significant association was found between mortality and age, sex, surgical procedure, catheter-related candidemia, or Candida spp. infection. The most frequently isolated Candida sp. was C. albicans (51%). Overall resistance rates to fluconazole, voriconazole, caspofungin, micafungin, and flucytosine were 3.7%, 0%, 2.5%, 1.8%, and 1.8%, respectively. Consequently, there is a need for tests that provide higher success rates, rapid diagnosis of candidemia, and local epidemiological data on antifungal resistance.

【 授权许可】

Unknown